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Title: Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine
Author: Just Baringo, Xavier
Bruno, Paolo
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Productes naturals
Síntesi de pèptids
Compostos heterocíclics
Natural products
Peptide synthesis
Heterocyclic compounds
Issue Date: 16-Aug-2011
Publisher: Elsevier Ltd
Abstract: (S)-2-(4-Bromo-2,4"-bithiazole)-1-(tert-butoxycarbonyl)pyrrolidine ((S)-1) was obtained as a single enantiomer and in high yield by means of a two-step modified Hantzsch thiazole synthesis reaction when bromoketone 3 and thioamide (S)-4 were used. Further conversion of (S)-1 into trimethyltin derivative (S)-2 broadens the scope for further cross-coupling reactions.
Note: Versió postprint del document publicat a:
It is part of: Tetrahedron Letters, 2011, vol. 52, num. 42, p. 5435-5437
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ISSN: 0040-4039
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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