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http://hdl.handle.net/2445/55263
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DC Field | Value | Language |
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dc.contributor.author | Lorente Crivillé, Adriana | - |
dc.contributor.author | Pla Queral, Daniel | - |
dc.contributor.author | Cañedo, Librada M. | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | Álvarez Domingo, Mercedes | - |
dc.date.accessioned | 2014-06-27T07:01:44Z | - |
dc.date.available | 2014-06-27T07:01:44Z | - |
dc.date.issued | 2010-11-23 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/2445/55263 | - |
dc.description.abstract | Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines. Based on preliminary one- and two-dimensional 1H- and 13C-NMR spectra, the natural compound was initially assigned the structure of macrolactone-type compound 1, which was later prepared by two different routes. However, major spectroscopic differences between isolated barmumycin and 1 led to revision of the proposed structure as E-16. Based on synthesis of this new compound, and subsequent spectroscopic comparison of it to an authentic sample of barmumycin, the structure of the natural compound was indeed confirmed as that of E-16. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1021/jo101834c | - |
dc.relation.ispartof | Journal of Organic Chemistry, 2010, vol. 75, num. 24, p. 8508-8515 | - |
dc.relation.uri | http://dx.doi.org/10.1021/jo101834c | - |
dc.rights | (c) American Chemical Society , 2010 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Medicaments antineoplàstics | - |
dc.subject.classification | Productes naturals marins | - |
dc.subject.classification | Lactones | - |
dc.subject.classification | Imidazoles | - |
dc.subject.other | Antineoplastic agents | - |
dc.subject.other | Marine natural products | - |
dc.subject.other | Lactones | - |
dc.subject.other | Imidazoles | - |
dc.title | Isolation, structural assignment and total synthesis of Barmumycin | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 585960 | - |
dc.date.updated | 2014-06-27T07:01:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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585960.pdf | 268.05 kB | Adobe PDF | View/Open |
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