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http://hdl.handle.net/2445/55267
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DC Field | Value | Language |
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dc.contributor.author | Hernández Romero, Delia | - |
dc.contributor.author | Riego, Estela | - |
dc.contributor.author | Francesch, Andrés | - |
dc.contributor.author | Cuevas, Carmen | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | Álvarez Domingo, Mercedes | - |
dc.date.accessioned | 2014-06-27T08:22:41Z | - |
dc.date.available | 2014-06-27T08:22:41Z | - |
dc.date.issued | 2007-07-10 | - |
dc.identifier.issn | 0040-4020 | - |
dc.identifier.uri | http://hdl.handle.net/2445/55267 | - |
dc.description.abstract | Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously obtained for the macrocyclization of more flexible structures in the syntheses of YM-216391, telomestatin, and IB-01211. Lastly, the preliminary results of anti-tumor activity screening of the synthesized analogs are discussed. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.tet.2007.06.103 | - |
dc.relation.ispartof | Tetrahedron, 2007, vol. 63, num. 39, p. 9862-9870 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.tet.2007.06.103 | - |
dc.rights | (c) Elsevier B.V., 2007 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Productes naturals | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Síntesi orgànica | - |
dc.subject.classification | Compostos heterocíclics | - |
dc.subject.other | Natural products | - |
dc.subject.other | Peptides | - |
dc.subject.other | Organic synthesis | - |
dc.subject.other | Heterocyclic compounds | - |
dc.title | Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 555878 | - |
dc.date.updated | 2014-06-27T08:22:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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555878.pdf | 179.9 kB | Adobe PDF | View/Open |
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