Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/55583
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGimeno-Bayon, Javier-
dc.contributor.authorLópez-López, A.-
dc.contributor.authorRodríguez Allué, Manuel José-
dc.contributor.authorMahy Gehenne, Josette Nicole-
dc.date.accessioned2014-07-08T07:12:51Z-
dc.date.available2015-02-07T23:02:13Z-
dc.date.issued2014-02-07-
dc.identifier.issn0360-4012-
dc.identifier.urihttp://hdl.handle.net/2445/55583-
dc.description.abstractWith its capacity to survey the environment and phagocyte debris, microglia assume a diversity of phenotypes to respond specifically through neurotrophic and toxic effects. Although these roles are well accepted, the underlying energetic mechanisms associated with microglial activation remain largely unclear. This study investigates microglia metabolic adaptation to ATP, NADPH, H(+) , and reactive oxygen species production. To this end, in vitro studies were performed with BV-2 cells before and after activation with lipopolysaccharide + interferon-γ. Nitric oxide (NO) was measured as a marker of cell activation. Our results show that microglial activation triggers a metabolic reprogramming based on an increased glucose uptake and a strengthening of anaerobic glycolysis, as well as of the pentose pathway oxidative branch, while retaining the mitochondrial activity. Based on this energy commitment, microglial defense capacity increases rapidly as well as ribose-5-phosphate and nucleic acid formation for gene transcription, essential to ensure the newly acquired functions demanded by central nervous system signaling. We also review the role of NO in this microglial energy commitment that positions cytotoxic microglia within the energetics of the astrocyte-neuron lactate shuttle.-
dc.format.extent60 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1002/jnr.23356-
dc.relation.ispartofJournal of Neuroscience Research, 2014, vol. 92, num. 6, p. 723-731-
dc.relation.urihttp://dx.doi.org/10.1002/jnr.23356-
dc.rights(c) Wiley, 2014-
dc.subject.classificationGlucòlisi-
dc.subject.classificationPentoses-
dc.subject.classificationÒxid nítric-
dc.subject.classificationMicròglia-
dc.subject.otherGlycolysis-
dc.subject.otherPentoses-
dc.subject.otherNitric oxide-
dc.subject.otherMicroglia-
dc.titleGlucose pathways adaptation supports acquisition of activated microglia phenotype-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec635165-
dc.date.updated2014-07-08T07:12:51Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

Files in This Item:
File Description SizeFormat 
635165.pdf4.92 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.