Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/55769
Title: Transfer entropy reconstruction and labeling of neuronal connections from simulated calcium imaging
Author: Orlandi, Javier G.
Stetter, Olav
Soriano i Fradera, Jordi
Geisel, Theo
Battaglia, Demian
Keywords: Xarxes neuronals (Neurobiologia)
Algorismes computacionals
Simulació per ordinador
Sinapsi
Bioinformàtica
Topologia
Neuroquímica
Neural networks (Neurobiology)
Computer algorithms
Computer simulation
Synapses
Bioinformatics
Topology
Neurochemistry
Issue Date: 6-Jun-2014
Publisher: Public Library of Science (PLoS)
Abstract: Neuronal dynamics are fundamentally constrained by the underlying structural network architecture, yet much of the details of this synaptic connectivity are still unknown even in neuronal cultures in vitro. Here we extend a previous approach based on information theory, the Generalized Transfer Entropy, to the reconstruction of connectivity of simulated neuronal networks of both excitatory and inhibitory neurons. We show that, due to the model-free nature of the developed measure, both kinds of connections can be reliably inferred if the average firing rate between synchronous burst events exceeds a small minimum frequency. Furthermore, we suggest, based on systematic simulations, that even lower spontaneous inter-burst rates could be raised to meet the requirements of our reconstruction algorithm by applying a weak spatially homogeneous stimulation to the entire network. By combining multiple recordings of the same in silico network before and after pharmacologically blocking inhibitory synaptic transmission, we show then how it becomes possible to infer with high confidence the excitatory or inhibitory nature of each individual neuron.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0098842
It is part of: PLoS One, 2014, vol. 9, num. 6, p. e98842
Related resource: http://dx.doi.org/10.1371/journal.pone.0098842
URI: http://hdl.handle.net/2445/55769
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Física Quàntica i Astrofísica)

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