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Title: | Metallic pseudopeptidic macrocycles. Study of molecular recognition processes of amino acids |
Other Titles: | Macrocicles pseudopeptídics metàl·lics. Estudi de processos de reconeixement molecular d'aminoàcids |
Author: | Sintes Marcos, Miquel |
Director/Tutor: | Rodríguez Raurell, Laura Alfonso Rodríguez, Ignacio |
Keywords: | Reconeixement molecular Química supramolecular Treballs de fi de grau Molecular recognition Supramolecular chemistry Bachelor's theses |
Issue Date: | Jun-2014 |
Abstract: | The aim of this work is the synthesis of the chiral pseudopeptidic macrocycle 5b and its use, together with analogue macrocycle 5a (Scheme 1) as ligands for Cu2+, in molecular recognition processes of amino acids. The two dinuclear complexes will be used as receptors in molecular recognition processes. The synthesis of the [2+2] pseudopeptidic macrocycle through a reductive amination is carried out by using an anionic template which places the four subunits in the right orientation for their union. The obtained product is characterized by ESI-MS and NMR. Copper complexes are prepared starting with the meta macrocycle and its para analogue. The resulting products are characterized by ESI MS. A comparative study of many amino acids and analogues behavior with the two macrocyclic complexes is carried out by UV-Vis spectrophotometry. After that, recognition tests are made with the two possible Malate isomers and association constants values are calculated for both isomers with macrocyclic copper complex. |
Note: | Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2014, Tutors: Dra. Laura Rodríguez Raurell i Dr. Ignacio Alfonso Rodríguez |
URI: | http://hdl.handle.net/2445/55774 |
Appears in Collections: | Treballs Finals de Grau (TFG) - Química |
Files in This Item:
File | Description | Size | Format | |
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TFG_QU Sintes_Marcos_Miquel.pdf | 2.14 MB | Adobe PDF | View/Open |
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