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Title: Metallic pseudopeptidic macrocycles. Study of molecular recognition processes of amino acids
Other Titles: Macrocicles pseudopeptídics metàl·lics. Estudi de processos de reconeixement molecular d'aminoàcids
Author: Sintes Marcos, Miquel
Director: Rodríguez Raurell, Laura
Alfonso Rodríguez, Ignacio
Keywords: Reconeixement molecular
Química supramolecular
Molecular recognition
Supramolecular chemistry
Issue Date: Jun-2014
Abstract: The aim of this work is the synthesis of the chiral pseudopeptidic macrocycle 5b and its use, together with analogue macrocycle 5a (Scheme 1) as ligands for Cu2+, in molecular recognition processes of amino acids. The two dinuclear complexes will be used as receptors in molecular recognition processes. The synthesis of the [2+2] pseudopeptidic macrocycle through a reductive amination is carried out by using an anionic template which places the four subunits in the right orientation for their union. The obtained product is characterized by ESI-MS and NMR. Copper complexes are prepared starting with the meta macrocycle and its para analogue. The resulting products are characterized by ESI MS. A comparative study of many amino acids and analogues behavior with the two macrocyclic complexes is carried out by UV-Vis spectrophotometry. After that, recognition tests are made with the two possible Malate isomers and association constants values are calculated for both isomers with macrocyclic copper complex.
Note: Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2014, Tutors: Dra. Laura Rodríguez Raurell i Dr. Ignacio Alfonso Rodríguez
Appears in Collections:Treballs Finals de Grau (TFG) - Química

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