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Title: Response to topical clonazepam in patients with burning mouth syndrome: a clinical study
Author: Rodríguez de Rivera Campillo, Ma Eugenia
López López, José, 1958-
Chimenos Küstner, Eduardo
Keywords: Malalties de la boca
Malalties de les glàndules salivals
Higiene bucal
Mouth diseases
Salivary gland diseases
Oral hygiene
Issue Date: May-2010
Publisher: Groupement International pour la Recherche Scientifique en Stomatologie et Odontologie
Abstract: Burning Mouth Syndrome (BMS) is a difficult disease for patients and clinicians. Moreover, there is not a general consensus on how to treat the disease. The main objective of this paper is to evaluate BMS patients' response to topical clonazepam treatment. A double blind study was performed. Among a total of 66 patients, 33 were treated with tablets of clonazepam and another 33 were treated with a placebo. Symptoms were evaluated after 1 month and 6 months of treatment and scored on an analogical scale from 0 to 10. Among the 33 patients treated with clonazepam, 23 showed at least a 50% reduction in symptoms after 1 month of treatment. On the contrary, only 4 in the placebo group exhibited significant improvement. After 6 months, significant differences were observed again, as 23 of the 33 patients treated with the drug reported at least a 50% reduction in symptoms, whereas only 2 among those treated with the placebo significantly improved. However, when measured in terms of a complete cure (lack of symptoms), the differences were not significant: 5 drug-treated patients and one belonging to the placebo group were asymptomatic after one month of treatment. In summary, it seems that clonazepam applied topically was effective in treating BMS in a large proportion of patients
Note: Reproducció del document publicat a:
It is part of: Bulletin du GIRSO, 2010, vol. 49, num. 1, p. 19-29
ISSN: 0250-4693
Appears in Collections:Articles publicats en revistes (Odontostomatologia)

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