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http://hdl.handle.net/2445/56025
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DC Field | Value | Language |
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dc.contributor.author | Pla Queral, Daniel | - |
dc.contributor.author | Martí, M. | - |
dc.contributor.author | Farrera Sinfreu, Josep Maria | - |
dc.contributor.author | Pulido, Daniel | - |
dc.contributor.author | Francesch, Andrés | - |
dc.contributor.author | Calvo, Pilar | - |
dc.contributor.author | Cuevas, Carmen | - |
dc.contributor.author | Royo Expósito, Miriam | - |
dc.contributor.author | Aligué i Alemany, Rosa Maria | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | Álvarez Domingo, Mercedes | - |
dc.date.accessioned | 2014-07-18T11:34:35Z | - |
dc.date.available | 2014-07-18T11:34:35Z | - |
dc.date.issued | 2009-05-27 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | http://hdl.handle.net/2445/56025 | - |
dc.description.abstract | The design and synthesis of Lamellarin D conjugates with a nuclear localization signal peptide and a poly(ethylene glycol)-based dendrimer are described. Conjugates 1-4 were obtained in 8-84% overall yields from the corresponding protected Lamellarin D. Conjugates 1 and 4 are 1.4 to 3.3-fold more cytotoxic than the parent compound against three human tumor cell lines(MDA-MB-231 breast, A-549 lung, and HT-29 colon). Besides, conjugates 3, 4 showed a decrease in activity potency in BJ skin fibroblasts, a normal cell culture. Cellular internalization was analyzed and nuclear distribution pattern was observed for 4, which contains a nuclear localization signalling sequence. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1021/bc800504t | - |
dc.relation.ispartof | Bioconjugate Chemistry, 2009, vol. 20, num. 6, p. 1112-1121 | - |
dc.relation.uri | http://dx.doi.org/10.1021/bc800504t | - |
dc.rights | (c) American Chemical Society , 2009 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Compostos heterocíclics | - |
dc.subject.classification | Medicaments antineoplàstics | - |
dc.subject.classification | Productes naturals marins | - |
dc.subject.classification | Transport biològic | - |
dc.subject.classification | Isoquinolina | - |
dc.subject.other | Heterocyclic compounds | - |
dc.subject.other | Antineoplastic agents | - |
dc.subject.other | Marine natural products | - |
dc.subject.other | Biological transport | - |
dc.subject.other | Isoquinoline | - |
dc.title | Lamellarin D bioconjugates II: synthesis and cellular internalization of dendrimer and nuclear location signal derivatives | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 564963 | - |
dc.date.updated | 2014-07-18T11:34:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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564963.pdf | 644.64 kB | Adobe PDF | View/Open |
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