Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/56043
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pla Queral, Daniel | - |
dc.contributor.author | Francesch, Andrés | - |
dc.contributor.author | Calvo, Pilar | - |
dc.contributor.author | Cuevas, Carmen | - |
dc.contributor.author | Aligué i Alemany, Rosa Maria | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | Álvarez Domingo, Mercedes | - |
dc.date.accessioned | 2014-07-18T11:43:58Z | - |
dc.date.available | 2014-07-18T11:43:58Z | - |
dc.date.issued | 2009-05-27 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | http://hdl.handle.net/2445/56043 | - |
dc.description.abstract | Herein is reported the design and synthesis of poly(ethylene glycol) derivatives of Lamellarin D with the aim of modulating their physicochemical properties, and improving the biological activity. Mono-, di- and tri-PEG conjugates with improved solubility were obtained in 18-57% overall yields from the corresponding partially protected phenolic derivatives of Lamellarin D. Conjugates 1-9 were tested in a panel of three human tumor cell lines (MDA-MB-231 breast, A-549 lung and HT-29 colon) to evaluate their cytotoxicity. Several compounds exhibited enhanced cellular internalization, and more than 85% of the derivatives showed a lower GI50 than Lam-D. Furthermore, cell cycle arrest at G2 phase, and apoptotic cell-death pathways were determined for Lamellarin D and these derivatives. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1021/bc800503k | - |
dc.relation.ispartof | Bioconjugate Chemistry, 2009, vol. 20, num. 6, p. 1100-1111 | - |
dc.relation.uri | http://dx.doi.org/10.1021/bc800503k | - |
dc.rights | (c) American Chemical Society , 2009 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Compostos heterocíclics | - |
dc.subject.classification | Medicaments antineoplàstics | - |
dc.subject.classification | Transport biològic | - |
dc.subject.classification | Isoquinolina | - |
dc.subject.other | Heterocyclic compounds | - |
dc.subject.other | Antineoplastic agents | - |
dc.subject.other | Biological transport | - |
dc.subject.other | Isoquinoline | - |
dc.title | Lamellarin D bioconjugates I: synthesis and cellular internalization of PEG-derivatives | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 564962 | - |
dc.date.updated | 2014-07-18T11:43:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 19472995 | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
564962.pdf | 2.09 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.