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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/56045
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dc.contributor.authorHernández Romero, Delia-
dc.contributor.authorAltuna, Marta-
dc.contributor.authorCuevas, Carmen-
dc.contributor.authorAligué i Alemany, Rosa Maria-
dc.contributor.authorAlbericio Palomera, Fernando-
dc.contributor.authorÁlvarez Domingo, Mercedes-
dc.date.accessioned2014-07-18T11:58:36Z-
dc.date.available2014-07-18T11:58:36Z-
dc.date.issued2008-09-03-
dc.identifier.issn0022-2623-
dc.identifier.urihttp://hdl.handle.net/2445/56045-
dc.description.abstractSeveral analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1021/jm800513w-
dc.relation.ispartofJournal of Medicinal Chemistry, 2008, vol. 51, num. 18, p. 5722-5730-
dc.relation.urihttp://dx.doi.org/10.1021/jm800513w-
dc.rights(c) American Chemical Society , 2008-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationCompostos heterocíclics-
dc.subject.classificationMedicaments antineoplàstics-
dc.subject.classificationSíntesi de pèptids-
dc.subject.classificationEspectroscòpia de ressonància magnètica nuclear-
dc.subject.otherHeterocyclic compounds-
dc.subject.otherAntineoplastic agents-
dc.subject.otherPeptide synthesis-
dc.subject.otherNuclear magnetic resonance spectroscopy-
dc.titleSynthesis and antitumor activity of mechercharmycin A analogues-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec564958-
dc.date.updated2014-07-18T11:58:37Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
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