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DC Field | Value | Language |
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dc.contributor.advisor | Nicolás Galindo, Ernesto | - |
dc.contributor.author | Codina Francès, Maria del Mar | - |
dc.date.accessioned | 2014-07-21T08:44:04Z | - |
dc.date.available | 2014-07-21T08:44:04Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/56084 | - |
dc.description | Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2014, Tutor: Dr. Ernesto Nicolás Galindo | ca |
dc.description.abstract | This work has been done in collaboration with the Bioinorganic Chemistry group of Inorganic Chemistry Department. This group is interested in chelating oligopeptides (about 3 or 4 amino acids) for metal ions such as copper and zinc, potential theranostic agents for Alzheimer disease. 1 Thereby we have synthesized peptides that contain at least two histidine residues (as metal-binding groups) and one natural or non-natural fluorescent amino acid (for detection purposes). We have used as fluorescent amino acids: tryptophan (W), tyrosine (T) and the non-natural amino acid Nε-(coumarin-3-ylcarbonyl)-L-Lysine (K(C)). The latter has been prepared in solution by reaction of 1H-benzotriazole with 2-oxo-2H-chromene-3-carboxylic acid to yield 3-(1Hbenzotriazol- 1-ylcarbonyl)-2H-chromen-2-one (52-60%) and the subsequent transformation of this intermediate to the final product by reaction with Fmoc-L-Lys-OH under basic condition (60- 85% yield). It has been characterized by proton nuclear magnetic resonance (1H-NMR). The synthesized peptides have been: histidine-alanine-histidine (HAH), histidine-alaninehistidine- tyrosine (HAHY), histidine-histidine-tryptophan (HHW), histidine-lysine(coumarin)- histidine (HK(C)H) and histidine-tryptophan-histidine (HWH) (Figure 1). HAH is the only one that hasn’t any fluorophore, but it has used as a blank to determine if fluorescent amino acid chelates the metal... | ca |
dc.format.extent | 63 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.rights | cc-by-nc-nd (c) Codina Francès, 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Treballs Finals de Grau (TFG) - Química | - |
dc.subject.classification | Pèptids | cat |
dc.subject.classification | Quelants | cat |
dc.subject.classification | Malaltia d'Alzheimer | cat |
dc.subject.classification | Treballs de fi de grau | cat |
dc.subject.other | Peptides | eng |
dc.subject.other | Chelating agents | eng |
dc.subject.other | Alzheimer's disease | eng |
dc.subject.other | Bachelor's theses | eng |
dc.title | Synthesis of tripeptides for chelating metals involved in the aggregation of the ß-amyloid peptide responsible for Alzheimer disease | eng |
dc.title.alternative | Síntesi de tripèptids quelants de metalls involucrats en l'agregació del pèptid ß-amiloide responsable de la malaltia de l’Alzheimer. | cat |
dc.type | info:eu-repo/semantics/bachelorThesis | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
Appears in Collections: | Treballs Finals de Grau (TFG) - Química |
Files in This Item:
File | Description | Size | Format | |
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TFG_Codina_Frances_Mar.pdf | 1.81 MB | Adobe PDF | View/Open |
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