Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/56092
Title: Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's Disease
Author: Bosch, N.
Pugliese, Marco
Gimeno-Bayon, Javier
Rodríguez Allué, Manuel José
Mahy Gehenne, Josette Nicole
Keywords: Malaltia d'Alzheimer
Models animals en la investigació
Gos
Alzheimer's disease
Animal models in research
Dog
Issue Date: 15-Mar-2012
Publisher: Bentham Science Publishers
Abstract: In the search for appropriate models for Alzheimer's disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping to elucidate the cascade of events that take place in brain amyloid-beta (Aβ)deposition aging, and cognitive deficit. Recent innovative research has validated human methods and tools for the analysis of canine neuropathology and has allowed the development of two different approaches to investigate dogs as natural models of AD. The first approach relates AD-like neuropathy with the decline in memory and learning ability in aged housed dogs in a highly controlled laboratory environment. The second approach involves research in family-owned animals with cognitive dysfunction syndrome. In this review, we compare the strengths and limitations of housed and family-owned canine models, and appraise their usefulness for deciphering the early mechanisms of AD and developing innovative therapies.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.2174/156720512800107546
It is part of: Current Alzheimer Research, 2012, vol. 9, num. 3, p. 298-314
Related resource: http://dx.doi.org/10.2174/156720512800107546
URI: http://hdl.handle.net/2445/56092
ISSN: 1567-2050
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

Files in This Item:
File Description SizeFormat 
598410.pdf6.56 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.