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http://hdl.handle.net/2445/56203
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DC Field | Value | Language |
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dc.contributor.author | Martínez-Clemente, José | - |
dc.contributor.author | López Arnau, Raúl | - |
dc.contributor.author | Abad, Sonia | - |
dc.contributor.author | Pubill Sánchez, David | - |
dc.contributor.author | Escubedo Rafa, Elena | - |
dc.contributor.author | Camarasa García, Jordi | - |
dc.date.accessioned | 2014-07-22T10:09:48Z | - |
dc.date.available | 2014-07-22T10:09:48Z | - |
dc.date.issued | 2014-06-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/56203 | - |
dc.description.abstract | Mephedrone is a drug of abuse marketed as 'bath salts'. There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in mice following different exposition schedules. Schedule 1: four doses of 50 mg/kg. Schedule 2: four doses of 25 mg/kg. Schedule 3: three daily doses of 25 mg/kg, for two consecutive days. All schedules induced, in some animals, an aggressive behavior and hyperthermia as well as a decrease in weight gain. Mephedrone (schedule 1) induced dopaminergic and serotoninergic neurotoxicity that persisted 7 days after exposition. At a lower dose (schedule 2) only a transient dopaminergic injury was found. In the weekend consumption pattern (schedule 3), mephedrone induced dopamine and serotonin transporter loss that was accompanied by a decrease in tyrosine hydroxylase and tryptophan hydroxylase 2 expression one week after exposition. Also, mephedrone induced a depressive-like behavior, as well as a reduction in striatal D2 density, suggesting higher susceptibility to addictive drugs. In cultured cortical neurons, mephedrone induced a concentration-dependent cytotoxic effect. Using repeated doses for 2 days in an elevated ambient temperature we evidenced a loss of frontal cortex dopaminergic and hippocampal serotoninergic neuronal markers that suggest injuries at nerve endings. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0099002 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 6, p. e99002 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0099002 | - |
dc.rights | cc-by (c) Martínez-Clemente, José et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Amfetamines | - |
dc.subject.classification | Lòbul frontal | - |
dc.subject.classification | Neurotoxicologia | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.classification | Sistema nerviós central | - |
dc.subject.other | Amphetamines | - |
dc.subject.other | Frontal lobe | - |
dc.subject.other | Neurotoxicology | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.subject.other | Central nervous system | - |
dc.title | Dose and time-dependent selective neurotoxicity induced by mephedrone in mice. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 641809 | - |
dc.date.updated | 2014-07-22T10:09:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24892744 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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641809.pdf | 1.04 MB | Adobe PDF | View/Open |
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