Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/56825
Title: ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
Author: Krämer, Ulrike M.
Rojo, N.
Schule, R.
Cunillera, Toni
Schols, L.
Marco Pallarés, Josep
Cucurell, David
Camara Mancha, Estela
Antoni Rodriguez-Fornells
Münte, Thomas F.
Keywords: Neurotransmissors
Dopamina
Neurofisiologia
Neurotransmitters
Dopamine
Neurophysiology
Issue Date: 20-Dec-2009
Publisher: BioMed Central
Abstract: Background Dopamine is believed to be a key neurotransmitter in the development of attention-deficit/ hyperactivity disorder (ADHD). Several recent studies point to an association of the dopamine D4 receptor (DRD4) gene and this condition. More specifically, the 7 repeat variant of a variable number of tandem repeats (VNTR) polymorphism in exon III of this gene is suggested to bear a higher risk for ADHD. In the present study, we investigated the role of this polymorphism in the modulation of neurophysiological correlates of response inhibition (Go/Nogo task) in a healthy, high-functioning sample. Results Homozygous 7 repeat carriers showed a tendency for more accurate behavior in the Go/Nogo task compared to homozygous 4 repeat carriers. Moreover, 7 repeat carriers presented an increased nogo-related theta band response together with a reduced go-related beta decrease. Conclusions These data point to improved cognitive functions and prefrontal control in the 7 repeat carriers, probably due to the D4 receptor's modulatory role in prefrontal areas. The results are discussed with respect to previous behavioral data on this polymorphism and animal studies on the impact of the D4 receptor on cognitive functions.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1186/1471-2202-10-150; http://dx.doi.org/10.1186/1471-2202-10-150
It is part of: BMC Neuroscience, 2009, vol. 10, num. 150
URI: http://hdl.handle.net/2445/56825
ISSN: 1471-2202
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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