Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/57126
Title: Thiopeptide antibiotics: retrospective and recent advances
Author: Just Baringo, Xavier
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Síntesi orgànica
Antibiòtics
Productes naturals
Pèptids
Organic synthesis
Antibiotics
Natural products
Peptides
Issue Date: 17-Jan-2014
Publisher: MDPI
Abstract: Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3390/md12010317
It is part of: Marine Drugs, 2014, vol. 12, num. 1, p. 317-351
Related resource: http://dx.doi.org/10.3390/md12010317
URI: http://hdl.handle.net/2445/57126
ISSN: 1660-3397
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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