Please use this identifier to cite or link to this item:
Title: Thiopeptide antibiotics: retrospective and recent advances
Author: Just Baringo, Xavier
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Síntesi orgànica
Productes naturals
Organic synthesis
Natural products
Issue Date: 17-Jan-2014
Publisher: MDPI
Abstract: Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.
Note: Reproducció del document publicat a:
It is part of: Marine Drugs, 2014, vol. 12, num. 1, p. 317-351
Related resource:
ISSN: 1660-3397
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
636464.pdf2.64 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons