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Title: Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness
Author: Bielanska, Joanna
Hernández-Losa, Javier
Moline, Terersa
Somoza, Rosa
Ramón y Cajal Agüeras, Santiago
Condom i Mundó, Enric
Ferreres, Joan C.
Felipe Campo, Antonio
Keywords: Leucòcits
Fisiologia cel·lular
Canals de potassi
Cell physiology
Potassium channels
Issue Date: 16-May-2012
Publisher: Spandidos Publications
Abstract: Voltage-dependent K+ channels (Kv) are involved in the proliferation and differentiation of mammalian cells, since Kv antagonists impair cell cycle progression. Although myofibers are terminally differentiated, some myoblasts may re-enter the cell cycle and proliferate. Since Kv1.3 and Kv1.5 expression is remodeled during tumorigenesis and is involved in smooth muscle proliferation, the purpose of this study was to analyze the expression of Kv1.3 and Kv1.5 in smooth muscle neoplasms. In the present study, we examined human samples of smooth muscle tumors together with healthy speci­mens. Thus, leiomyoma (LM) and leiomyosarcoma (LMS) tumors were analyzed. Results showed that Kv1.3 was poorly expressed in the healthy muscle and indolent LM specimens, whereas aggressive LMS showed high levels of Kv1.3 expression. Kv1.5 staining was correlated with malignancy. The findings show a remodeling of Kv1.3 and Kv1.5 in human smooth muscle sarcoma. A correlation of Kv1.3 and Kv1.5 expression with tumor aggressiveness was observed. Thus, our results indicate Kv1.5 and Kv1.3 as potential tumorigenic targets for aggressive human LMS.
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It is part of: Oncology Letters, 2012, vol. 4, p. 227-230
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ISSN: 1792-1074
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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