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http://hdl.handle.net/2445/59013
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DC Field | Value | Language |
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dc.contributor.author | Torrens, Juana María | - |
dc.contributor.author | Orellana Gavaldà, Josep Maria | - |
dc.contributor.author | Palou, Mariona | - |
dc.contributor.author | Sánchez, Juana | - |
dc.contributor.author | Herrero Rodríguez, Laura | - |
dc.contributor.author | Picó, Catalina | - |
dc.contributor.author | Serra i Cucurull, Dolors | - |
dc.contributor.author | Palou Oliver, Andreu | - |
dc.date.accessioned | 2014-10-24T14:34:36Z | - |
dc.date.available | 2014-10-24T14:34:36Z | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1015-8987 | - |
dc.identifier.uri | http://hdl.handle.net/2445/59013 | - |
dc.description.abstract | Background/Aims: Moderate maternal calorie-restriction during gestation programmes offspring for a major propensity to develop metabolic alterations in adulthood. We aimed to assess whether increased hepatic fatty-acid oxidation (FAO), at early ages, by gene transfer of Cpt1am (active mutant of carnitine palmitoyltransferase-1a), may be a strategy for reversing metabolic disturbances associated to maternal calorie-restriction during gestation in rats. Methods: AAV-Gfp (control) and AAV-Cpt1am vectors were administered by tail vein injection in 18-day-old control-pups and the offspring of 20% calorie-restricted rats during gestation (CR). After weaning, animals were fed with normal-fat diet. At the age of 4 months, they were moved to HF-diet and sacrificed at the age of 6 months to collect tissues. Locomotive activity, energy expenditure and blood pressure were measured. Results: Under HF-diet, CR-animals showed higher HOMA-IR, adipocyte diameter and hepatic triglyceride accumulation than controls; these alterations were reverted in Cpt1am-injected animals. In liver, this treatment ameliorated inflammatory state, decreased expression of lipogenesis-related genes and partially restored the decreased expression of leptin-receptor occurring in CR-animals. Treatment also reverted the decreased energy expenditure and the increased blood pressure of CR-animals. Conclusion: Increasing hepatic FAO through AAV-Cpt1am injection at juvenile ages prevents some metabolic disorders associated to gestational maternal calorie-restriction. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Karger | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1159/000358714 | - |
dc.relation.ispartof | Cellular Physiology and Biochemistry, 2014, vol. 33, num. 5, p. 1498-1515 | - |
dc.relation.uri | http://dx.doi.org/10.1159/000358714 | - |
dc.rights | (c) Karger, 2014 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Àcids grassos | - |
dc.subject.classification | Dieta hipocalòrica | - |
dc.subject.classification | Fetge | - |
dc.subject.classification | Teràpia genètica | - |
dc.subject.classification | Malnutrició | - |
dc.subject.classification | Complicacions en l'embaràs | - |
dc.subject.classification | Trastorns del metabolisme | - |
dc.subject.other | Fatty acids | - |
dc.subject.other | Low-calorie diet | - |
dc.subject.other | Liver | - |
dc.subject.other | Gene therapy | - |
dc.subject.other | Malnutrition | - |
dc.subject.other | Disorders of metabolism | - |
dc.subject.other | Complications of pregnancy | - |
dc.title | Enhancing hepatic fatty acid oxidation as a strategy for reversing metabolic disorders programmed by maternal undernutrition during gestation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 637431 | - |
dc.date.updated | 2014-10-24T14:34:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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637431.pdf | 1.74 MB | Adobe PDF | View/Open |
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