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http://hdl.handle.net/2445/59200
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DC Field | Value | Language |
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dc.contributor.author | Almuedo Castillo, María | - |
dc.contributor.author | Crespo, Xenia | - |
dc.contributor.author | Saló i Boix, Emili | - |
dc.contributor.author | Adell i Creixell, Teresa | - |
dc.contributor.author | Seebeck, F. | - |
dc.contributor.author | Bartscherer, Kerstin | - |
dc.date.accessioned | 2014-10-29T15:22:03Z | - |
dc.date.available | 2014-10-29T15:22:03Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.uri | http://hdl.handle.net/2445/59200 | - |
dc.description.abstract | Regeneration of lost tissues depends on the precise interpretation of molecular signals that control and coordinate the onset of proliferation, cellular differentiation and cell death. However, the nature of those molecular signals and the mechanisms that integrate the cellular responses remain largely unknown. The planarian flatworm is a unique model in which regeneration and tissue renewal can be comprehensively studied in vivo. The presence of a population of adult pluripotent stem cells combined with the ability to decode signaling after wounding enable planarians to regenerate a complete, correctly proportioned animal within a few days after any kind of amputation, and to adapt their size to nutritional changes without compromising functionality. Here, we demonstrate that the stress-activated c-jun-NH2-kinase (JNK) links wound-induced apoptosis to the stem cell response during planarian regeneration. We show that JNK modulates the expression of wound-related genes, triggers apoptosis and attenuates the onset of mitosis in stem cells specifically after tissue loss. Furthermore, in pre-existing body regions, JNK activity is required to establish a positive balance between cell death and stem cell proliferation to enable tissue renewal, remodeling and the maintenance of proportionality. During homeostatic degrowth, JNK RNAi blocks apoptosis, resulting in impaired organ remodeling and rescaling. Our findings indicate that JNK-dependent apoptotic cell death is crucial to coordinate tissue renewal and remodeling required to regenerate and to maintain a correctly proportioned animal. Hence, JNK might act as a hub, translating wound signals into apoptotic cell death, controlled stem cell proliferation and differentiation, all of which are required to coordinate regeneration and tissue renewal. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/ 10.1371/journal.pgen.1004400 | - |
dc.relation.ispartof | PLoS Genetics, 2014, vol. 10, num. 6 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pgen.1004400 | - |
dc.rights | cc-by (c) Almuedo Castillo, María et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Apoptosi | - |
dc.subject.classification | Mitosi | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.other | Apoptosis | - |
dc.subject.other | Mitosis | - |
dc.subject.other | Stem cells | - |
dc.title | JNK controls the onset of mitosis of planarian stem cells and triggers apoptotic cell death required for regeneration and remodeling | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 634708 | - |
dc.date.updated | 2014-10-29T15:22:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24922054 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
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634708.pdf | 2.97 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License