Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/59234
Title: Cardiovascular disease-related parameters and Oxidative stress in SHROB rats, a model for metabolic syndrome.
Author: Molinar-Toribio, E.
Pérez-Jiménez, J.
Ramos Romero, Sara
Lluís, L.
Sánchez-Martos, V.
Taltavull, N.
Romeu, Marta
Pazos, M.
Méndez, L.
Miranda, A.
Cascante i Serratosa, Marta
Medina, I.
Torres, J. L.
Keywords: Infermeria cardiovascular
Estrès oxidatiu
Síndrome metabòlica
Cardiovascular disease nursing
Oxidative stress
Metabolic syndrome
Issue Date: 12-Aug-2014
Publisher: Public Library of Science (PLoS)
Abstract: SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0104637
It is part of: PLoS One, 2014, vol. 9, num. 8
Related resource: http://dx.doi.org/10.1371/journal.pone.0104637
URI: http://hdl.handle.net/2445/59234
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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