Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/59884
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Berzigotti, Annalisa | - |
dc.contributor.author | Reverter, Enric | - |
dc.contributor.author | García-Criado, Angeles | - |
dc.contributor.author | González-Abraldes Iglesias, Juan | - |
dc.contributor.author | Cerini, Federica | - |
dc.contributor.author | García Pagán, Juan Carlos | - |
dc.contributor.author | Bosch i Genover, Jaume | - |
dc.date.accessioned | 2014-11-21T09:10:44Z | - |
dc.date.issued | 2013-05-10 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | http://hdl.handle.net/2445/59884 | - |
dc.description.abstract | BACKGROUND & AIMS: Hepatic blood flow (HBF) is best estimated by the Fick's method during indocyanine green constant infusion (ICG-HBF) on hepatic vein catheterization. We investigated the consistency and agreement of HBF measured by Doppler ultrasound (US-HBF) as compared with ICG-HBF in portal hypertensive patients with cirrhosis. METHODS: In 50 patients observed for HVPG measurement (56% compensated; Child score 7 ± 2; HVPG 16.6 ± 6.0 mmHg; varices in 75%) US-HBF (Sequoia-512-Acuson; 4.5-7 MHz convex probe; US-HBF = hepatic artery blood flow+portal vein blood flow) and ICG-HBF (Fick's method after an equilibration period of at least 45 min of ICG bolus of 5 mg + constant rate infusion of 0.2 mg/min). Intraclass correlation coefficient (ICC) for consistency and absolute agreement between US-HBF and ICG-HBF were calculated. RESULTS: Mean ICG-HBF and US-HBF were similar, being respectively 1004 ± 543 ml/min and 994 ± 494 ml/min (p = 0.661 vs. ICG-HBF). However, results in individual patients disclosed marked differences between the two methods (386 ± 415 ml/min) and showed only moderate consistency (ICC 0.456; p < 0.0001), absolute agreement (ICC 0.461; p < 0.0001) and linear correlation (R = 0.464; p < 0.0001). The discrepancy between the two methods was maximal in patients with poor liver function, high HBF by any technique and more arterialized liver circulation. Hepatic artery blood flow ≥40% of US-HBF indicated, with 90% specificity, a discrepancy ≥20% between US-HBF and ICG-HBF. CONCLUSIONS: HBF estimations by Doppler-ultrasound and ICG are significantly correlated, but their discrepancy in individual cases is high. Estimation of HBF by Doppler-US should be considered unreliable in patients with poor hepatic function and large liver arterialization. | - |
dc.format.extent | 27 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: http:/dx.doi.org/10.1016/j.jhep.2013.04.037 | - |
dc.relation.ispartof | Journal of Hepatology, 2013, vol. 59, num. 4, p. 717-722 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.jhep.2013.04.037 | - |
dc.rights | (c) Elsevier, 2013 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Hipertensió portal | - |
dc.subject.classification | Cirrosi hepàtica | - |
dc.subject.classification | Ecografia Doppler | - |
dc.subject.other | Portal hypertension | - |
dc.subject.other | Hepatic cirrhosis | - |
dc.subject.other | Doppler ultrasonography | - |
dc.title | Reliability of the estimation of total hepatic blood flow by doppler ultrasound in patients with cirrhotic portal hypertension | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 638264 | - |
dc.date.updated | 2014-11-21T09:10:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23669282 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
638264.pdf | 455.4 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.