Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/60525
Title: Purinergic receptors in ocular inflammation
Author: Guzman-Aranguez, A.
Gasull Casanova, Xavier
Diebold, Y.
Pintor, J.
Keywords: Inflamació
Adenosina
Nucleòtids
Oftalmologia
Inflammation
Adenosine
Nucleotides
Ophtalmology
Issue Date: 14-Jul-2014
Publisher: Hindawi Publishing Corporation
Abstract: Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly 'tuned,' can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P(1),P(4)-diadenosine tetraphosphate (Ap4A), and P(1),P(5)-diadenosine pentaphosphate (Ap5A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A3 receptor, selective agonists like N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1155/2014/320906
It is part of: Mediators of Inflammation, 2014, vol. 2014, p. 1-11
Related resource: http://dx.doi.org/10.1155/2014/320906
URI: http://hdl.handle.net/2445/60525
ISSN: 0962-9351
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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