Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/60569
Title: Ancient DNA analysis of 8000 B.C. near eastern farmers supports an early neolithic pioneer maritime colonization of Mainland Europe through Cyprus and the Aegean Islands
Author: Fernández Domínguez, Eva
Martínez Pérez-Pérez, Alejandro
Gamba, Cristina
Prats, E.
Cuesta, Pedro
Anfruns, Josep
Molist, Miquel, 1956-
Arroyo-Pardo, Eduardo
Turbón, Daniel
Keywords: Genètica forense
Neolític
Antropologia prehistòrica
ADN mitocondrial
Xipre
Egea (Mar)
Forensic genetics
Neolithic period
Prehistoric anthropology
Mitochondrial DNA
Cyprus
Aegean Sea
Issue Date: 5-Jun-2014
Publisher: Public Library of Science (PLoS)
Abstract: The genetic impact associated to the Neolithic spread in Europe has been widely debated over the last 20 years. Within this context, ancient DNA studies have provided a more reliable picture by directly analyzing the protagonist populations at different regions in Europe. However, the lack of available data from the original Near Eastern farmers has limited the achieved conclusions, preventing the formulation of continental models of Neolithic expansion. Here we address this issue by presenting mitochondrial DNA data of the original Near-Eastern Neolithic communities with the aim of providing the adequate background for the interpretation of Neolithic genetic data from European samples. Sixty-three skeletons from the Pre Pottery Neolithic B (PPNB) sites of Tell Halula, Tell Ramad and Dja'de El Mughara dating between 8,700-6,600 cal. B.C. were analyzed, and 15 validated mitochondrial DNA profiles were recovered. In order to estimate the demographic contribution of the first farmers to both Central European and Western Mediterranean Neolithic cultures, haplotype and haplogroup diversities in the PPNB sample were compared using phylogeographic and population genetic analyses to available ancient DNA data from human remains belonging to the Linearbandkeramik-Alföldi Vonaldiszes Kerámia and Cardial/Epicardial cultures. We also searched for possible signatures of the original Neolithic expansion over the modern Near Eastern and South European genetic pools, and tried to infer possible routes of expansion by comparing the obtained results to a database of 60 modern populations from both regions. Comparisons performed among the 3 ancient datasets allowed us to identify K and N-derived mitochondrial DNA haplogroups as potential markers of the Neolithic expansion, whose genetic signature would have reached both the Iberian coasts and the Central European plain. Moreover, the observed genetic affinities between the PPNB samples and the modern populations of Cyprus and Crete seem to suggest that the Neolithic was first introduced into Europe through pioneer seafaring colonization.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pgen.1004401
It is part of: PLoS Genetics, 2014, vol. 10, num. 6, p. e1004401
Related resource: http://dx.doi.org/10.1371/journal.pgen.1004401
URI: http://hdl.handle.net/2445/60569
ISSN: 1553-7390
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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