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Title: Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
Author: Amat Tusón, Mercedes
Köver, A.
Jokic, D.
Lozano, O.
Pérez Bosch, Maria
Landoni, N.
Subrizi, F.
Bautista, J.
Bosch Cartes, Joan
Keywords: Bioquímica
Dianes farmacològiques
Proteïnes quinases
Transducció de senyal cel·lular
Drug targeting
Protein kinases
Cellular signal transduction
Issue Date: 2010
Publisher: Michigan Publishing
Abstract: A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.
Note: Reproducció del document publicat a:
It is part of: Arkivoc, vol. 2010, núm. 3, p. 145-151
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ISSN: 1551-7012
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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