Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/61173
Title: Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.
Author: Merino Montero, Susana
Wilhelms, Markus
Tomàs Magaña, Juan
Keywords: Bacteris
Flagel·lats
Regulació genètica
Autoimmunitat
Bacteria
Flagellata
Genetic regulation
Autoimmunity
Issue Date: 28-Oct-2014
Publisher: MDPI
Abstract: Polar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous heptasaccharide glycan. Two mutants with altered (light and strong) polar flagella glycosylation still able to produce flagella were previously obtained, as well as mutants lacking the O34-antigen lipopolysaccharide (LPS) but with unaltered polar flagella glycosylation. We compared these mutants, altogether with the wild type strain, in different studies to conclude that polar flagella glycosylation is extremely important for A. hydrophila adhesion to Hep-2 cells and biofilm formation. Furthermore, the polar flagella glycosylation is an important factor for the immune stimulation of IL-8 production via toll receptor 5 (TLR5).
Note: Reproducció del document publicat a: http://dx.doi.org/10.3390/ijms151221935
It is part of: International Journal of Molecular Sciences, 2014, vol. 15, p. 21935-21946
Related resource: http://dx.doi.org/10.3390/ijms151221935
URI: http://hdl.handle.net/2445/61173
ISSN: 1422-0067
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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