Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/61463
Title: Mycobacterium tuberculosis Infection in Young Children: Analyzing the Performance of the Diagnostic Tests
Author: Pérez-Porcuna, Tomàs M.
Ascaso Terrén, Carlos
Malheiro, A.
Abellana Sangrà, Rosa Mari
Martins, M.
Jardim Sardinha, J.F.
Quincó P.
Antunes, I.A.
Garrido M.S.
Bührer-Sékula, S.
Martinez-Espinosa, F.E
Keywords: Mycobacterium tuberculosis
Tuberculosi
Helmints
Infància
Mycobacterium tuberculosis
Tuberculosis
Helminths
Childhood
Issue Date: 30-May-2014
Publisher: Public Library of Science (PLoS)
Abstract: This study evaluated the performance of the Tuberculin Skin Test (TST) and Quantiferon-TB Gold in-Tube (QFT) and the possible association of factors which may modify their results in young children (0-6 years) with recent contact with an index tuberculosis case. Materials and Methods: A cross-sectional study including 135 children was conducted in Manaus, Amazonas-Brazil. The TST and QFT were performed and the tests results were analyzed in relation to the personal characteristics of the children studied and their relationship with the index case. Results: The rates of positivity were 34.8% (TST) and 26.7% (QFT), with 14.1% of indeterminations by the QFT. Concordance between tests was fair (Kappa = 0.35 P<0.001). Both the TST and QFT were associated with the intensity of exposure (Linear OR = 1.286, P = 0.005; Linear OR = 1.161, P = 0.035 respectively) with only the TST being associated with the time of exposure (Linear OR = 1.149, P = 0.009). The presence of intestinal helminths in the TST+ group was associated with negative QFT results (OR = 0.064, P = 0.049). In the TST- group lower levels of ferritin were associated with QFT+ results (Linear OR = 0.956, P = 0.036). Conclusions: Concordance between the TST and QFT was lower than expected. The factors associated with the discordant results were intestinal helminths, ferritin levels and exposure time to the index tuberculosis case. In TST+ group, helminths were associated with negative QFT results suggesting impaired cell-mediated immunity. The TST-&QFT+ group had a shorter exposure time and lower ferritin levels, suggesting that QFT is faster and ferritin may be a potential biomarker of early stages of tuberculosis infection.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2014, vol. 9, num. 5
URI: http://hdl.handle.net/2445/61463
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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