Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/61724
Title: Wine, alcohol, polyphenols and cardiovascular disease
Author: Estruch Riba, Ramon
Lamuela Raventós, Rosa Ma.
Keywords: Vi
Polifenols
Malalties cardiovasculars
Consum d'alcohol
Estrès oxidatiu
Inflamació
Wine
Polyphenols
Cardiovascular diseases
Drinking of alcoholic beverages
Oxidative stress
Inflammation
Issue Date: 12-Jun-2014
Publisher: IOS Press
Abstract: Abstract. Excessive alcohol consumption is associated with increased morbidity and mortality as well as with labour and traffic accidents. However, current evidence suggests beneficial effects of moderate drinking on cardiovascular events including coronary heart disease, ischaemic stroke, peripheral arterial disease and congestive heart failure. The underlying mechanisms to explain these protective effects against coronary heart disease include an increase in high-density lipoprotein cholesterol and an increase in insulin sensitivity, and a decrease in platelet aggregation and circulating concentrations of fibrinogen. However, there are discrepancies regarding the specific effects of different types of beverages on the cardiovascular system, and also whether the possible protective effects of alcoholic beverages are due to their alcohol component (ethanol) or non-alcoholic products containing, mainly polyphenols. Recent randomised clinical trials have shown that wine, a polyphenol-rich alcoholic beverage, provides higher antioxidant and anti-inflammatory effects than some spirits such as gin, a polyphenol-free alcoholic beverage. In addition, dealcoholized red wine decreases blood pressure through a nitric oxide mediated mechanism, suggesting a protective effect of polyphenols on vascular function. Other studies performed in women have observed that daily doses of 15<br>20 g of alcohol as red wine are sufficient to elicit protective effects similar to those observed in men who consumed higher doses of wine. In conclusion, moderate consumption of wine exerts a protective effect on biomarkers related to the progression and development of atherosclerosis due to its alcoholic (ethanol) and non-alcoholic (polyphenols) content. Women are more sensitive to the beneficial effects of wine.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3233/NUA-140039
It is part of: Nutrition and Aging, 2014, vol. 2, num. 2-3, p. 101-109
Related resource: http://dx.doi.org/10.3233/NUA-140039
URI: http://hdl.handle.net/2445/61724
ISSN: 1879-7717
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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