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Title: Green tea catechin inhibits fatty acid synthase without stimulating carnitine Palmitoyltransferase-1 or inducing weight loss in experimental animals
Author: Puig i Miquel, Teresa
Relat Pardo, Joana
Marrero González, Pedro F.
Haro Bautista, Diego
Brunet, Joan
Colomer Bosch, Ramón
Keywords: Àcids grassos
Quimioteràpia del càncer
Medicaments antineoplàstics
Efectes secundaris dels medicaments
Càncer de mama
Fatty acids
Cancer chemotherapy
Antineoplastic agents
Drug side effects
Breast cancer
Weight loss
Issue Date: Nov-2008
Publisher: International Institute of Anticancer Research
Abstract: Background: The enzyme fatty acid synthase (FASN) is highly expressed in many human carcinomas and its inhibition is cytotoxic to human cancer cells. The use of FASN inhibitors has been limited until now by anorexia and weight loss, which is associated with the stimulation of fatty acid oxidation. Materials and Methods: The in vitro effect of (-)-epigallocatechin-3-gallate (EGCG) on fatty acid metabolism enzymes, on apoptosis and on cell signalling was evaluated. In vivo, the effect of EGCG on animal body weight was addressed. Results: EGCG inhibited FASN activity, induced apoptosis and caused a marked decrease of human epidermal growth factor receptor 2 (HER2), phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular (signal)-regulated kinase (ERK) 1/2 proteins, in breast cancer cells. EGCG did not induce a stimulatory effect on CPT-1 activity in vitro (84% of control), or on animal body weight in vivo (99% of control). Conclusion: EGCG is a FASN inhibitor with anticancer activity which does not exhibit cross-activation of fatty acid oxidation and does not induce weight loss, suggesting its potential use as an anticancer drug.
Note: Reproducció del document publicat a:
It is part of: Anticancer Research, 2008, vol. 28, num. 6A, p. 3671-3676
ISSN: 0250-7005
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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