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http://hdl.handle.net/2445/62005
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DC Field | Value | Language |
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dc.contributor.author | Turapov, Obolbek | - |
dc.contributor.author | Waddell, Simon J. | - |
dc.contributor.author | Burke, Bernard | - |
dc.contributor.author | Glenn, Sarah | - |
dc.contributor.author | Sarybaeva, Asel A. | - |
dc.contributor.author | Tudó i Vilanova, Griselda | - |
dc.contributor.author | Labesse, Gilles | - |
dc.contributor.author | Young, Danielle I. | - |
dc.contributor.author | Young, Michael | - |
dc.contributor.author | Andrew, Peter W. | - |
dc.contributor.author | Butcher, Philip D. | - |
dc.contributor.author | Cohen Gonsaun, Martin | - |
dc.contributor.author | Mukamolova, Galina | - |
dc.date.accessioned | 2015-01-29T08:36:42Z | - |
dc.date.available | 2015-01-29T08:36:42Z | - |
dc.date.issued | 2014-07-10 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/2445/62005 | - |
dc.description.abstract | We have recently shown that RaaS (regulator of antimicrobial-assisted survival), encoded by Rv1219c in Mycobacterium tuberculosis and by bcg_1279c in Mycobacterium bovis bacillus Calmette-Guérin, plays an important role in mycobacterial survival in prolonged stationary phase and during murine infection. Here, we demonstrate that long chain acyl-CoA derivatives (oleoyl-CoA and, to lesser extent, palmitoyl-CoA) modulate RaaS binding to DNA and expression of the downstream genes that encode ATP-dependent efflux pumps. Moreover, exogenously added oleic acid influences RaaS-mediated mycobacterial improvement of survival and expression of the RaaS regulon. Our data suggest that long chain acyl-CoA derivatives serve as biological indicators of the bacterial metabolic state. Dysregulation of efflux pumps can be used to eliminate non-growing mycobacteria. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Biochemistry and Molecular Biology | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1074/jbc.M114.577338 | - |
dc.relation.ispartof | Journal of Biological Chemistry, 2014, vol. 289, num. 36, p. 25241-25249 | - |
dc.relation.uri | http://dx.doi.org/10.1074/jbc.M114.577338 | - |
dc.rights | cc by (c) Turapov et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Mycobacterium tuberculosis | - |
dc.subject.classification | Àcid oleic | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Mycobacterium tuberculosis | - |
dc.subject.other | Oleic acid | - |
dc.subject.other | Antibiotics | - |
dc.title | Oleoyl Coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in Mycobacteria | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 643442 | - |
dc.date.updated | 2015-01-29T08:36:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25012658 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
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643442.pdf | 1.49 MB | Adobe PDF | View/Open |
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