Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/62165
Title: Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight
Author: Laguna Egea, Juan Carlos
Alegret i Jordà, Marta
Roglans i Ribas, Núria
Keywords: Fructosa
Malalties del fetge
Càncer de fetge
Obesitat
Resistència a la insulina
Fructose
Liver diseases
Liver cancer
Obesity
Insulin resistance
Issue Date: 22-Dec-2014
Publisher: MDPI
Abstract: Sugar intake has dramatically increased during the last few decades. Specifically, there has been a clear trend towards higher consumption of fructose and high fructose corn syrup, which are the most common added sugars in processed food, soft drinks and other sweetened beverages. Although still controversial, this rising trend in simple sugar consumption has been positively associated with weight gain and obesity, insulin resistance and type 2 diabetes mellitus and non-alcoholic fatty liver disease. Interestingly, all of these metabolic alterations have also been related to the development of hepatocellular carcinoma. The purpose of this review is to discuss the evidence coming from epidemiological studies and data from animal models relating the consumption of simple sugars, and specifically fructose, with an increased risk of hepatocellular carcinoma and to gain insight into the putative molecular mechanisms involved.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3390/nu6125933
It is part of: Nutrients, 2014, vol. 6, num. 12, p. 5933-5954
Related resource: http://dx.doi.org/10.3390/nu6125933
URI: http://hdl.handle.net/2445/62165
ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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