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DC Field | Value | Language |
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dc.contributor.author | Laguna Egea, Juan Carlos | - |
dc.contributor.author | Alegret i Jordà, Marta | - |
dc.contributor.author | Roglans i Ribas, Núria | - |
dc.date.accessioned | 2015-02-01T11:31:03Z | - |
dc.date.available | 2015-02-01T11:31:03Z | - |
dc.date.issued | 2014-12-22 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/62165 | - |
dc.description.abstract | Sugar intake has dramatically increased during the last few decades. Specifically, there has been a clear trend towards higher consumption of fructose and high fructose corn syrup, which are the most common added sugars in processed food, soft drinks and other sweetened beverages. Although still controversial, this rising trend in simple sugar consumption has been positively associated with weight gain and obesity, insulin resistance and type 2 diabetes mellitus and non-alcoholic fatty liver disease. Interestingly, all of these metabolic alterations have also been related to the development of hepatocellular carcinoma. The purpose of this review is to discuss the evidence coming from epidemiological studies and data from animal models relating the consumption of simple sugars, and specifically fructose, with an increased risk of hepatocellular carcinoma and to gain insight into the putative molecular mechanisms involved. | - |
dc.format.extent | 22 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3390/nu6125933 | - |
dc.relation.ispartof | Nutrients, 2014, vol. 6, num. 12, p. 5933-5954 | - |
dc.relation.uri | http://dx.doi.org/10.3390/nu6125933 | - |
dc.rights | cc-by (c) Laguna Egea, Juan Carlos et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Fructosa | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.classification | Càncer de fetge | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Resistència a la insulina | - |
dc.subject.other | Fructose | - |
dc.subject.other | Liver diseases | - |
dc.subject.other | Liver cancer | - |
dc.subject.other | Obesity | - |
dc.subject.other | Insulin resistance | - |
dc.title | Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 645544 | - |
dc.date.updated | 2015-02-01T11:31:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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645544.pdf | 317.35 kB | Adobe PDF | View/Open |
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