Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/62752
Title: Clotting activity of polyphosphate-functionalized silica nanoparticles
Author: Kudela, Damien
Smith, Stephanie A.
May Masnou, Anna
Braun, Gary B.
Pallaoro, Alessia
Nguyen, Chi K.
Chuong, Tracy T.
Nownes, Sara
Allen, Riley
Parker, Nicholas R.
Rashidi, Hooman H.
Morrissey, James H.
Stucky, Galen D.
Keywords: Silici
Nanopartícules
Silicats
Ferides i lesions
Hemorràgia
Silicon
Nanoparticles
Silicates
Wounds and injuries
Hemorrhage
Issue Date: 29-Jan-2015
Publisher: Wiley-VCH
Abstract: We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.
Note: Versió postprint del document publicat a: http://doi.org/10.1002/ange.201409639
It is part of: Angewandte Chemie, 2015, vol. 127, num. 3
Related resource: http://dx.doi.org/10.1002/ange.201409639
URI: http://hdl.handle.net/2445/62752
ISSN: 0044-8249
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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