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http://hdl.handle.net/2445/62752
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DC Field | Value | Language |
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dc.contributor.author | Kudela, Damien | - |
dc.contributor.author | Smith, Stephanie A. | - |
dc.contributor.author | May Masnou, Anna | - |
dc.contributor.author | Braun, Gary B. | - |
dc.contributor.author | Pallaoro, Alessia | - |
dc.contributor.author | Nguyen, Chi K. | - |
dc.contributor.author | Chuong, Tracy T. | - |
dc.contributor.author | Nownes, Sara | - |
dc.contributor.author | Allen, Riley | - |
dc.contributor.author | Parker, Nicholas R. | - |
dc.contributor.author | Rashidi, Hooman H. | - |
dc.contributor.author | Morrissey, James H. | - |
dc.contributor.author | Stucky, Galen D. | - |
dc.date.accessioned | 2015-02-11T09:34:09Z | - |
dc.date.available | 2016-01-29T23:01:31Z | - |
dc.date.issued | 2015-01-29 | - |
dc.identifier.issn | 0044-8249 | - |
dc.identifier.uri | http://hdl.handle.net/2445/62752 | - |
dc.description.abstract | We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://doi.org/10.1002/ange.201409639 | - |
dc.relation.ispartof | Angewandte Chemie, 2015, vol. 127, num. 3 | - |
dc.relation.uri | http://dx.doi.org/10.1002/ange.201409639 | - |
dc.rights | (c) Wiley-VCH, 2015 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Silici | - |
dc.subject.classification | Nanopartícules | - |
dc.subject.classification | Silicats | - |
dc.subject.classification | Ferides i lesions | - |
dc.subject.classification | Hemorràgia | - |
dc.subject.other | Silicon | - |
dc.subject.other | Nanoparticles | - |
dc.subject.other | Silicates | - |
dc.subject.other | Wounds and injuries | - |
dc.subject.other | Hemorrhage | - |
dc.title | Clotting activity of polyphosphate-functionalized silica nanoparticles | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 646608 | - |
dc.date.updated | 2015-02-11T09:34:11Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25651530 | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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646608.pdf | 709.29 kB | Adobe PDF | View/Open |
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