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Title: Oxygen pathway modeling estimates high Reactive oxygen species production above the highest permanent human habitation.
Author: Cano Franco, Isaac
Selivanov, Vitaly A.
Gomez Cabrero, David
Tegnér, Jesper
Roca Torrent, Josep
Wagner, P. D. (Peter D.)
Cascante i Serratosa, Marta
Keywords: Oxigen en l'organisme
Oxygen in the body
Issue Date: 6-Nov-2014
Publisher: Public Library of Science (PLoS)
Abstract: The production of reactive oxygen species (ROS) from the inner mitochondrial membrane is one of many fundamental processes governing the balance between health and disease. It is well known that ROS are necessary signaling molecules in gene expression, yet when expressed at high levels, ROS may cause oxidative stress and cell damage. Both hypoxia and hyperoxia may alter ROS production by changing mitochondrial Po2 (). Because depends on the balance between O2 transport and utilization, we formulated an integrative mathematical model of O2 transport and utilization in skeletal muscle to predict conditions to cause abnormally high ROS generation. Simulations using data from healthy subjects during maximal exercise at sea level reveal little mitochondrial ROS production. However, altitude triggers high mitochondrial ROS production in muscle regions with high metabolic capacity but limited O2 delivery. This altitude roughly coincides with the highest location of permanent human habitation. Above 25,000 ft., more than 90% of exercising muscle is predicted to produce abnormally high levels of ROS, corresponding to the "death zone" in mountaineering.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2014, vol. 9, num. 11, p. e111068
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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