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Title: Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.
Author: Martínez González, Javier
Lisa, Silvia
Sánchez, Rosa
Kowalczyk, Wioleta
Zurita, Esther
Teixidó Turà, Meritxell
Giralt Lledó, Ernest
Andreu Martínez, David
Avila, Jesús
Gasset, María
Keywords: Biofísica
Síntesi de pèptids
Malalties neurodegeneratives
Citotoxicitat per mediació cel·lular
Peptide synthesis
Neurodegenerative diseases
Amino acids
Cell-mediated cytotoxicity
Issue Date: 2011
Publisher: Public Library of Science (PLoS)
Abstract: The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2011, vol. 6, num. 11, p. e27999
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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