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http://hdl.handle.net/2445/62905| Title: | Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity. |
| Author: | Martínez González, Javier Lisa, Silvia Sánchez, Rosa Kowalczyk, Wioleta Zurita, Esther Teixidó Turà, Meritxell Giralt Lledó, Ernest Andreu Martínez, David Avila, Jesús Gasset, María |
| Keywords: | Biofísica Síntesi de pèptids Malalties neurodegeneratives Aminoàcids Citotoxicitat per mediació cel·lular Polímers Oxidació Biophysics Peptide synthesis Neurodegenerative Diseases Amino acids Cell-mediated cytotoxicity Polymers Oxidation |
| Issue Date: | 2011 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties. |
| Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0027999 |
| It is part of: | PLoS One, 2011, vol. 6, num. 11, p. e27999 |
| URI: | http://hdl.handle.net/2445/62905 |
| Related resource: | http://dx.doi.org/10.1371/journal.pone.0027999 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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|---|---|---|---|---|
| 605680.pdf | 1.83 MB | Adobe PDF | View/Open |
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