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Title: Loss of intestinal epithelial barrier function in Salmonella Enteritidis infection
Author: Martín Venegas, Raquel
Brufau Bonet, M. Teresa (Maria Teresa)
Ferrer i Roig, Ruth
Keywords: Salmonel·la
Malalties inflamatòries intestinals
Fisiologia patològica
Inflammatory bowel diseases
Pathological physiology
Issue Date: 2014
Publisher: Research Signpost
Abstract: Intestinal infection with Salmonella enterica serotype Enteritidis, a food-borne infection spread to humans especially through contaminated eggs and egg-products as well as undercooked contaminated fresh meat, is the most common cause of intestinal inflammation in the European Union. Enteritis caused by Salmonella Enteritidis is characterized by fever, diarrhoea and abdominal pain. The disruption of the intestinal epithelial barrier function contributes to diarrhoea and is responsible for the perpetuation of the inflammatory process. In this sense, oxidative stress and the proinflammatory cytokines TNF-α, IFN-γ and IL-1β are described to induce the disorganization of the tight junctions (TJ), the most apical epithelial intercellular junctions and responsible for the paracellular permeability. The interest of this chapter relies not only in the investigation dealing with the mechanisms of TJ regulation but also in the contribution to the development of new tools for the prevention of epithelial barrier disruption in enteritis caused by Salmonella Enteritidis.
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It is part of: Recent Advances in Pharmaceutical Sciences IV, 2014, Research Signpost : Editors: Diego Muñoz Torrero, Manuel Vázquez-Carrera & Joan Estelrich i Latràs. ISBN: 978-81-308-0554-2. Chapter 5, p. 73-84.
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Appears in Collections:Llibres / Capítols de llibre (Bioquímica i Fisiologia)

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