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Title: Synthetic approaches towards the Lycopodium alkaloids
Author: Bradshaw, Ben
Saborit Villarroya, Gisela
Luque-Corredera, Carlos
Balañà, Marta
Bonjoch i Sesé, Josep
Keywords: Pteridòfits
Síntesi orgànica
Organic synthesis
Issue Date: 2014
Publisher: Research Signpost
Abstract: The Lycopodium alkaloids are a structurally diverse group of natural products isolated from Lycopodium with important biological effects for the potential treatment of cancer and severe neurodegenerative diseases. To date, full biological studies have been hampered by lack of material from natural sources. Total synthesis represents a possible solution to meet this demand as well as the most effective way to design new compounds to determine structural activity relationships and obtain more potent compounds. The aim of this chapter is to summarise the work carried out in this field so far by presenting an overview of the synthetic strategies used to access each of the four key Lycopodium alkaloid types. Particular emphasis has been placed on methods that rapidly construct each nucleus utilizing tandem reactions.
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It is part of: Recent Advances in Pharmaceutical Sciences IV, 2014, Research Signpost: Editors: Diego Muñoz Torrero, Manuel Vázquez-Carrera & Joan Estelrich i Latràs. ISBN: 978-81-308-0554-2. Chapter 10, p. 143-163.
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Appears in Collections:Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)
Llibres / Capítols de llibre (Institut de Biomedicina (IBUB))

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