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Title: Review and new therapeutic alternatives for the treatment of cutaneous Leishmaniasis
Author: Pujol Brugués, Alba
Riera Lizandra, Ma. Cristina
Keywords: Leishmaniosi
Issue Date: 2014
Publisher: Research Signpost
Abstract: Leishmaniasis comprises a group of diseases caused by protozoa of the genus Leishmania and has two basic clinical forms, visceral Leishmaniasis and cutaneous Leishmaniasis. The clinical features of Leishmaniasis depend on the species of Leishmania, the interaction between host and parasite and the immune response. This work focuses on cutaneous leishmaniosis because although it is not a deadly disease it results in significant scars and facial disfigurements, thus being clinically important. Furthermore, the first-line treatment consists of intravenous or intramuscular administration of intralesional pentavalent antimonials, which are highly toxic, making hospitalization of patients compulsory during treatment, with the associated financial costs. Herein, we review studies on drugs and treatments with fewer side effects and easier routes of administration such as topical administration. Recent research shows that the topical route of administration holds promise for the future treatment of cutaneous leishmaniosis.
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It is part of: Recent Advances in Pharmaceutical Sciences IV, 2014, Research Signpost : Editors: Diego Muñoz Torrero, Manuel Vázquez-Carrera & Joan Estelrich i Latràs. ISBN: 978-81-308-0554-2. Chapter 12, p. 181-201.
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Appears in Collections:Llibres / Capítols de llibre (Biologia, Sanitat i Medi Ambient)

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