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Title: Potential of caveolae in the therapy of cardiovascular and neurological diseases.
Author: Navarro, Gemma
Borroto-Escuela, Dasiel O.
Fuxe, Kjell
Franco Fernández, Rafael
Keywords: Malalties del sistema nerviós
Membranes cel·lulars
Malalties cardiovasculars
Proteïnes de membrana
Nervous System Diseases
Cell membranes
Cardiovascular diseases
Membrane proteins
Issue Date: 30-Sep-2014
Publisher: Frontiers Media
Abstract: Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.
Note: Reproducció del document publicat a:
It is part of: Frontiers in Physiology , 2014, vol. 5, p. 1-8
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ISSN: 1664-042X
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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