Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/64766
Title: Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?
Author: Franco Fernández, Rafael
Cedazo-Mínguez, Ángel
Keywords: Malaltia d'Alzheimer
Experimentació animal
Cura dels malalts
Alzheimer's disease
Animal experimentation
Care of the sick
Issue Date: 25-Jun-2014
Publisher: Frontiers Media
Abstract: Peering into the field of Alzheimer's disease (AD), the outsider realizes that many of the therapeutic strategies tested (in animal models) have been successful. One also may notice that there is a deficit in translational research, i.e., to take a successful drug in mice and translate it to the patient. Efforts are still focused on novel projects to expand the therapeutic arsenal to 'cure mice.' Scientific reasons behind so many successful strategies are not obvious. This article aims to review the current approaches to combat AD and to open a debate on common mechanisms of cognitive enhancement and neuroprotection. In short, either the rodent models are not good and should be discontinued, or we should extract the most useful information from those models. An example of a question that may be debated for the advancement in AD therapy is: In addition to reducing amyloid and tau pathologies, would it be necessary to boost synaptic strength and cognition? The debate could provide clues to turn around the current negative output in generating effective drugs for patients. Furthermore, discovery of biomarkers in human body fluids, and a clear distinction between cognitive enhancers and disease modifying strategies, should be instrumental for advancing in anti-AD drug discovery.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fphar.2014.00146
It is part of: Frontiers in Pharmacology, 2014, vol. 5, p. 1-13
Related resource: http://dx.doi.org/10.3389/fphar.2014.00146
URI: http://hdl.handle.net/2445/64766
ISSN: 1663-9812
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
649527.pdf1 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons