Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/64890
Title: Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century
Author: Franco Fernández, Rafael
Navarro Brugal, Gemma
Martínez-Pinilla, E.
Moreno Guillén, Estefanía
Keywords: Malaltia d'Alzheimer
Expressió gènica
Proteïnes de membrana
Alzheimer's disease
Gene expression
Membrane proteins
Issue Date: 29-Dec-2014
Publisher: Annex Publishers
Abstract: The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function. APP is anchored to the membrane and displays a single C-terminal intracellular domain and a longer N-terminal extracellular domain. The basic biochemical properties and the scattered data on research, not related to production of beta-amyloid peptide, suggest that the protein and the molecules resulting from APP proteolytic cleavage may act as adhesion factors, enzymes, hormones/neurotransmitters and/or protease inhibitors. APP deserves to be known for its quite notable properties and its physiological role(s).
Note: Reproducció del document publicat a: http://www.annexpublishers.com/articles/JNND/volume-1-issue-1/Amyloid-Beta-Precursor-Protein-Proper-Credit-for-the-Basic-Biochemical-Properties-of-the
It is part of: Journal of Neurology and Neurological Disorders, 2014, vol. 1, num. 1, p. 1-6
URI: http://hdl.handle.net/2445/64890
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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