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http://hdl.handle.net/2445/65198
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DC Field | Value | Language |
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dc.contributor.author | Riga, Maurizio S. | - |
dc.contributor.author | Soria, Guadalupe | - |
dc.contributor.author | Tudela Fernández, Raúl | - |
dc.contributor.author | Artigas Pérez, Francesc | - |
dc.contributor.author | Celada Pedrosa, Paz | - |
dc.date.accessioned | 2015-04-24T10:42:44Z | - |
dc.date.available | 2015-04-24T10:42:44Z | - |
dc.date.issued | 2014-03-20 | - |
dc.identifier.issn | 1461-1457 | - |
dc.identifier.uri | http://hdl.handle.net/2445/65198 | - |
dc.description.abstract | 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual, religious and healing purposes that is being increasingly used for recreational purposes in US and Europe. 5MeO-DMT is of potential interest for schizophrenia research owing to its hallucinogenic properties. Two other psychotomimetic agents, phencyclidine and 2,5-dimethoxy-4-iodo-phenylisopropylamine (DOI), markedly disrupt neuronal activity and reduce the power of low frequency cortical oscillations (<4 Hz, LFCO) in rodent medial prefrontal cortex (mPFC). Here we examined the effect of 5-MeO-DMT on cortical function and its potential reversal by antipsychotic drugs. Moreover, regional brain activity was assessed by blood-oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). 5-MeO-DMT disrupted mPFC activity, increasing and decreasing the discharge of 51 and 35% of the recorded pyramidal neurons, and reducing (−31%) the power of LFCO. The latter effect depended on 5-HT1A and 5-HT2A receptor activation and was reversed by haloperidol, clozapine, risperidone, and the mGlu2/3 agonist LY379268. Likewise, 5-MeO-DMT decreased BOLD responses in visual cortex (V1) and mPFC. The disruption of cortical activity induced by 5-MeO-DMT resembles that produced by phencyclidine and DOI. This, together with the reversal by antipsychotic drugs, suggests that the observed cortical alterations are related to the psychotomimetic action of 5-MeO-DMT. Overall, the present model may help to understand the neurobiological basis of hallucinations and to identify new targets in antipsychotic drug development. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1017/S1461145714000261 | - |
dc.relation.ispartof | International Journal of Neuropsychopharmacology, 2014, vol. 17, num. 8, p. 1269-1282 | - |
dc.relation.uri | http://dx.doi.org/10.1017/S1461145714000261 | - |
dc.rights | (c) CINP (Collegium Internationale Neuro-Psychopharmacologicum) , 2014 | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Antipsicòtics | - |
dc.subject.classification | Al·lucinògens | - |
dc.subject.classification | Receptors de serotonina | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.other | Antipsychotic drugs | - |
dc.subject.other | Hallucinogenic drugs | - |
dc.subject.other | Serotonin receptors | - |
dc.subject.other | Schizophrenia | - |
dc.title | The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 650995 | - |
dc.date.updated | 2015-04-24T10:42:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24650558 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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650995.pdf | 933.64 kB | Adobe PDF | View/Open |
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