Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/65530
Title: Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
Author: López Arnau, Raúl
Martínez-Clemente, J.
Pubill Sánchez, David
Escubedo Rafa, Elena
Camarasa García, Jordi
Keywords: Amfetamines
Neurotoxicologia
Sistema nerviós central
Hipocamp (Cervell)
Lòbul frontal
Rates (Animals de laboratori)
Trastorns de la memòria
Amphetamines
Neurotoxicology
Central nervous system
Hippocampus (Brain)
Frontal lobe
Rats as laboratory animals
Memory disorders
Issue Date: 28-Nov-2014
Publisher: Sage Publications
Abstract: Methylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated the neurochemical/enzymatic changes indicative of neurotoxicity after methylone administration (4 × 20 mg/kg, subcutaneously, per day with 3 h intervals) to adolescent rats, to model human recreational use. In addition, we studied the effect of methylone on spatial learning ad memory using the Morris water maze paradigm. Our experiments were carried out at a high ambient temperature to simulate the hot conditions found in dance clubs where the drug is consumed. We observed a hyperthermic response to methylone that reached a peak 30 min after each dose. We determined a serotonergic impairment in methylone-treated rats, especially in the frontal cortex, where it was accompanied by astrogliosis. Some serotonergic alterations were also present in the hippocampus and striatum. No significant neurotoxic effect on the dopaminergic system was identified. Methylone-treated animals only displayed impairments in the probe trial of the Morris water maze, which concerns reference memory, while the spatial learning process seemed to be preserved.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1177/0269881114548439
It is part of: Journal of Psychopharmacology, 2014, vol. 28, num. 11, p. 1053-1063
Related resource: http://dx.doi.org/10.1177/0269881114548439
URI: http://hdl.handle.net/2445/65530
ISSN: 0269-8811
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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