Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/65530
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLópez Arnau, Raúl-
dc.contributor.authorMartínez-Clemente, José-
dc.contributor.authorPubill Sánchez, David-
dc.contributor.authorEscubedo Rafa, Elena-
dc.contributor.authorCamarasa García, Jordi-
dc.date.accessioned2015-05-13T14:37:14Z-
dc.date.available2015-05-13T14:37:14Z-
dc.date.issued2014-11-28-
dc.identifier.issn0269-8811-
dc.identifier.urihttp://hdl.handle.net/2445/65530-
dc.description.abstractMethylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated the neurochemical/enzymatic changes indicative of neurotoxicity after methylone administration (4 × 20 mg/kg, subcutaneously, per day with 3 h intervals) to adolescent rats, to model human recreational use. In addition, we studied the effect of methylone on spatial learning ad memory using the Morris water maze paradigm. Our experiments were carried out at a high ambient temperature to simulate the hot conditions found in dance clubs where the drug is consumed. We observed a hyperthermic response to methylone that reached a peak 30 min after each dose. We determined a serotonergic impairment in methylone-treated rats, especially in the frontal cortex, where it was accompanied by astrogliosis. Some serotonergic alterations were also present in the hippocampus and striatum. No significant neurotoxic effect on the dopaminergic system was identified. Methylone-treated animals only displayed impairments in the probe trial of the Morris water maze, which concerns reference memory, while the spatial learning process seemed to be preserved.-
dc.format.extent11 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSage Publications-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1177/0269881114548439-
dc.relation.ispartofJournal of Psychopharmacology, 2014, vol. 28, num. 11, p. 1053-1063-
dc.relation.urihttp://dx.doi.org/10.1177/0269881114548439-
dc.rights(c) López Arnau, Raúl et al., 2014-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationAmfetamines-
dc.subject.classificationNeurotoxicologia-
dc.subject.classificationSistema nerviós central-
dc.subject.classificationHipocamp (Cervell)-
dc.subject.classificationLòbul frontal-
dc.subject.classificationRates (Animals de laboratori)-
dc.subject.classificationTrastorns de la memòriacat
dc.subject.otherAmphetamines-
dc.subject.otherNeurotoxicology-
dc.subject.otherCentral nervous system-
dc.subject.otherHippocampus (Brain)-
dc.subject.otherFrontal lobe-
dc.subject.otherRats as laboratory animals-
dc.subject.otherMemory disorderseng
dc.titleSerotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec646921-
dc.date.updated2015-05-13T14:37:15Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid25237120-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
646921.pdf779.29 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.