Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/65652
Title: Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
Author: Fagundo, Ana Beatriz
Torre, Rafael de la
Jiménez-Murcia, Susana
Agüera, Zaida
Pastor, Antoni
Casanueva, Felipe F.
Granero, Roser
Baños Rivera, Rosa María
Botella Arbona, Cristina
Del Pino Gutiérrez, Amparo
Fernández-Real Lemos, José Manuel
Fernández García, José C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón Magriñá, José Manuel
Moragrega, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones, Francisco J.
Fernández Aranda, Fernando
Keywords: Cànnabis
Cognició
Presa de decisions
Endocrinologia
Cannabis
Cognition
Decision making
Endocrinology
Issue Date: 19-Jun-2013
Publisher: Public Library of Science (PLoS)
Abstract: Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0066387
It is part of: PLoS One, 2013, vol. 8, num. 6, p. 1-7
Related resource: http://dx.doi.org/10.1371/journal.pone.0066387
URI: http://hdl.handle.net/2445/65652
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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