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Title: Chapter One – Larock Reaction in the synthesis of heterocyclic compounds
Author: Herraiz Cobo, Jesús
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Química orgànica
Síntesi orgànica
Compostos heterocíclics
Organic chemistry
Organic synthesis
Heterocyclic compounds
Issue Date: 12-Dec-2015
Publisher: Elsevier
Abstract: The indole ring is one of the most common features in natural products and small molecules with important bioactivity. Larock reported a new methodology for the synthesis of the indole ring system based on the palladium-catalyzed heteroannulation of 2-iodoaniline and substituted alkyne moieties. This procedure was subsequently extended to the preparation of other nitrogen- and oxygen- containing heterocycles. This is the process of choice for the synthesis of a large number of heterocyclic derivatives, as it provides outstanding regioselectivity and good to excellent yields.
Note: Versió postprint del document publicat a:
It is part of: Advances in Heterocyclic Chemistry, 2015, vol. 116, p. 1-35
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ISSN: 0065-2725
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Química Inorgànica i Orgànica)

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