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DC Field | Value | Language |
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dc.contributor.author | Ascher-Svanum, Haya | - |
dc.contributor.author | Novick, Diego | - |
dc.contributor.author | Haro Abad, Josep Maria | - |
dc.contributor.author | Bertsch, Jordan | - |
dc.contributor.author | McDonnell, David | - |
dc.contributor.author | Detke, Holland | - |
dc.date.accessioned | 2015-06-08T11:55:32Z | - |
dc.date.available | 2015-06-08T11:55:32Z | - |
dc.date.issued | 2014-06-20 | - |
dc.identifier.issn | 1176-6328 | - |
dc.identifier.uri | http://hdl.handle.net/2445/65757 | - |
dc.description.abstract | BACKGROUND: Little is known about the long-term changes in the functioning of schizophrenia patients receiving maintenance therapy with olanzapine long-acting injection (LAI), and whether observed changes differ from those seen with oral olanzapine. METHODS: This study describes changes in the levels of functioning among outpatients with schizophrenia treated with olanzapine-LAI compared with oral olanzapine over 2 years. This was a secondary analysis of data from a multicenter, randomized, open-label, 2-year study comparing the long-term treatment effectiveness of monthly olanzapine-LAI (405 mg/4 weeks; n=264) with daily oral olanzapine (10 mg/day; n=260). Levels of functioning were assessed with the Heinrichs-Carpenter Quality of Life Scale. Functional status was also classified as 'good', 'moderate', or 'poor', using a previous data-driven approach. Changes in functional levels were assessed with McNemar's test and comparisons between olanzapine-LAI and oral olanzapine employed the Student's t-test. RESULTS: Over the 2-year study, the patients treated with olanzapine-LAI improved their level of functioning (per Quality of Life total score) from 64.0-70.8 (P<0.001). Patients on oral olanzapine also increased their level of functioning from 62.1-70.1 (P<0.001). At baseline, 19.2% of the olanzapine-LAI-treated patients had a 'good' level of functioning, which increased to 27.5% (P<0.05). The figures for oral olanzapine were 14.2% and 24.5%, respectively (P<0.001). Results did not significantly differ between olanzapine-LAI and oral olanzapine. CONCLUSION: In this 2-year, open-label, randomized study of olanzapine-LAI, outpatients with schizophrenia maintained or improved their favorable baseline level of functioning over time. Results did not significantly differ between olanzapine-LAI and oral olanzapine. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Dove Medical Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.2147/NDT.S61409 | - |
dc.relation.ispartof | Neuropsychiatric Disease And Treatment, 2014, vol. 10, p. 1125-1131 | - |
dc.relation.uri | http://dx.doi.org/10.2147/NDT.S61409 | - |
dc.rights | cc-by-nc (c) Ascher-Svanum, H. et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) | - |
dc.subject.classification | Antipsicòtics | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.classification | Qualitat de vida | - |
dc.subject.other | Antipsychotic drugs | - |
dc.subject.other | Schizophrenia | - |
dc.subject.other | Quality of life | - |
dc.title | Long-term functional improvements in the 2-year treatment of schizophrenia outpatients with olanzapine long-acting injection | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 649059 | - |
dc.date.updated | 2015-06-08T11:55:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25018631 | - |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
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649059.pdf | 211.67 kB | Adobe PDF | View/Open |
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