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Title: Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
Author: Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pérez Gómez, Beatriz
Martín Sánchez, Vicente
Llorca Díaz, Javier
Moreno Aguado, Víctor
Altzibar, Jone M.
Ardanaz, Eva
Sanjosé Llongueras, Silvia de
Jiménez Moleón, José J.
Tardón, Adonina
Alguacil, Juan
Peiró Pérez, Rosana
Marcos Gragera, Rafael
Navarro Sánchez, Carmen
Pollán, Marina
Kogevinas, Manolis
Keywords: Epidemiologia
Càncer colorectal
Càncer de pròstata
Càncer de mama
Colorectal cancer
Prostate cancer
Breast cancer
Issue Date: 19-Jan-2015
Publisher: Elsevier
Abstract: INTRODUCTION: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. METHODS: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. DISCUSSION: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.
Note: Versió postprint del document publicat a:
It is part of: Gaceta Sanitaria, 2015, vol. 29, num. 4, p. 308-315
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ISSN: 0213-9111
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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