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Title: Metabolomic pattern analysis after Mediterranean diet intervention in non-diabetic population: a 1- and 3-year follow-up in the PREDIMED study
Author: Vázquez Fresno, Rosa
Llorach, Rafael
Urpí Sardà, Mireia
Lupianez-Barbero, Ascensión
Estruch Riba, Ramon
Corella Piquer, Dolores
Fitó Colomer, Montserrat
Arós, Fernando
Ruiz-Canela, Miguel
Salas Salvadó, Jordi
Andrés Lacueva, Ma. Cristina
Keywords: Dieta
Cuina mediterrània
Dieta sense greix
Cuina (Nous)
Oli d'oliva
Ressonància magnètica nuclear
Mediterranean cooking
Low-fat diet
Cooking (Nuts)
Olive oil
Nuclear magnetic resonance
Issue Date: 29-Oct-2015
Publisher: American Chemical Society
Abstract: The Mediterranean diet (MD) is considered a dietary pattern with beneficial effects on human health. The aim of this study was to assess the effect of an MD on urinary metabolome by comparing subjects at 1 and 3 years of follow-up, after an MD supplemented with either extra-virgin olive oil (MD + EVOO) or nuts (MD + Nuts), to those on advice to follow a control low-fat diet (LFD). Ninety-eight nondiabetic volunteers were evaluated, using metabolomic approaches, corresponding to MD + EVOO (n = 41), MD + Nuts (n = 27), or LFD (n = 30) groups. The 1H NMR urinary profiles were examined at baseline and after 1 and 3 years of follow-up. Multivariate data analysis (OSC-PLS-DA and HCA) methods were used to identify the potential biomarker discriminating groups, exhibiting a urinary metabolome separation between MD groups against baseline and LFD. Results revealed that the most prominent hallmarks concerning MD groups were related to the metabolism of carbohydrates (3-hydroxybutyrate, citrate, and cis-aconitate), creatine, creatinine, amino acids (proline, N-acetylglutamine, glycine, branched-chain amino acids, and derived metabolites), lipids (oleic and suberic acids), and microbial cometabolites (phenylacetylglutamine and p-cresol). Otherwise, hippurate, trimethylamine-N-oxide, histidine and derivates (methylhistidines, carnosine, and anserine), and xanthosine were predominant after LFD. The application of NMR-based metabolomics enabled the classification of individuals regarding their dietary pattern and highlights the potential of this approach for evaluating changes in the urinary metabolome at different time points of follow-up in response to specific dietary interventions.
Note: Versió postprint del document publicat a:
It is part of: Journal of Proteome Research, 2015, vol. 14, num. 1, p. 531-540
Related resource:
ISSN: 1535-3893
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Medicina)

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