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http://hdl.handle.net/2445/66251
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DC Field | Value | Language |
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dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.contributor.author | Campa, Adela G. de la | - |
dc.contributor.author | García, Ernesto | - |
dc.contributor.author | Fenoll, Asunción | - |
dc.contributor.author | Calatayud, Laura | - |
dc.contributor.author | Cercenado, Emilia | - |
dc.contributor.author | Pérez Trallero, Emilio | - |
dc.contributor.author | Bouza, Emilio | - |
dc.contributor.author | Liñares Louzao, Josefina | - |
dc.date.accessioned | 2015-07-09T12:57:48Z | - |
dc.date.available | 2015-07-09T12:57:48Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1080-6040 | - |
dc.identifier.uri | http://hdl.handle.net/2445/66251 | - |
dc.description.abstract | Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Centers for Disease Control and Prevention | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3201/eid2011.131215 | - |
dc.relation.ispartof | Emerging Infectious Diseases, 2014, vol. 20, num. 11, p. 1848-1856 | - |
dc.relation.uri | http://dx.doi.org/10.3201/eid2011.131215 | - |
dc.rights | Domini públic / Public domain | - |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Pneumococs | - |
dc.subject.classification | Infeccions per pneumococs | - |
dc.subject.classification | Estreptococs | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Malalties de l'aparell respiratori | - |
dc.subject.classification | Malalties infeccioses | - |
dc.subject.classification | Espanya | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.subject.other | Pneumococcal Infections | - |
dc.subject.other | Streptococcus | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Respiratory organs diseases | - |
dc.subject.other | Communicable diseases | - |
dc.subject.other | Spain | - |
dc.title | Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 652337 | - |
dc.date.updated | 2015-07-09T12:57:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25340616 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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652337.pdf | 860.02 kB | Adobe PDF | View/Open |
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